One use-case that I think can be super useful is calling native APIs from the REPL. I had to build a custom camera component in Swift and I felt like going back to the dark ages, using the debugger, setting break points, etc. If I had a Clojure REPL into Swift/Objective-C (ideally Swift) the experience could potentially be much better.
I’m not sure how possible that would be… Since you’d have to compile some Objective-C on the fly and execute it? I believe that is possible (but I have never tried it myself, have only heard/read stories). Not sure about that strategy with Swift.
Just found this: https://github.com/johnno1962/InjectionIII
Perhaps worth a look.
I was able to get some basic objective-c interop working using https://developer.apple.com/documentation/objectivec/1456712-objc_msgsend?language=objc (along with a few other https://developer.apple.com/documentation/objectivec/objective-c_runtime?language=objc calls). I think that should enable most objective c interop, but I'm not sure how how easy it is to make a repl for Swift. I'll check out the project the InjectionIII project, but Swift seems overall less friendly for dynamic runtime interaction.
1This project (InjectionIII) actually seems like the real deal… It looks like you can eval Swift/Obj-C on the fly.